For Synapses, It's Depression Not Death
نویسندگان
چکیده
Long-term depression (LTD) of synaptic strength is an activity-dependent process in neurons that may be important for learning and memory. Li et al. (2010) now reveal a new apoptosis-independent role for mitochondrial-activated caspases in LTD suggesting that neurons have co-opted the canonical cell death pathway to perform a specialized function at synapses.
منابع مشابه
(S)- 3,5-Dihydroxyphenylglycine )an agonist for group I metabotropic glutamate receptors( induced synaptic potentiation at excitatory synapses on fast spiking GABAergic cells in visual cortex
Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cel...
متن کاملLong-term depression: a cell biological view.
Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses loca...
متن کاملPsychometric Properties of Death Depression Scale in Women with Breast Cancer
Background and Objectives: Accurate assessment of patients' death depression requires a specific tool that is appropriate to the culture of each community. Therefore, the aim of this study was to evaluate the psychometric properties of the Death Depression Scale in women with breast cancer. Methods: In this methodological study, 246 breast cancer patients presenting to Qazvin Provincial ...
متن کاملTesting and Comparing the Causal Relationship Between Spiritual and Social Capital and Depression With the Mediating Role of Death Anxiety in the Elderly With and Without a Spouse
Introduction: The world population is rapidly aging, and depression is a common mental disorder that is prevalent among the elderly in different countries. This study aimed to test the causal model of depression based on spiritual and social capital through death anxiety in the elderly. Materials and Methods: The statistical population included all the elderly in Tehran in 2020, from which 371...
متن کاملSpatiotemporal properties of microsaccades: Model predictions and experimental tests
Microsaccades are involuntary and very small eye movements during fixation. Recently, the microsaccade-related neural dynamics have been extensively investigated both in experiments and by constructing neural network models. Experimentally, microsaccades also exhibit many behavioral properties. It's well known that the behavior properties imply the underlying neural dynamical mechanisms, and so...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 141 شماره
صفحات -
تاریخ انتشار 2010